Yap1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comYap1 Polyclonal Antibody for Mouse(Mus musculus)

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Yap1 (Gene name),

Yorkie homolog (Protein name ), YAP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Yap1(Yap;Yap65);

Protein name:

Yorkie homolog;

Alternative:

65 kDa Yes-associated protein(YAP65);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with isoform JM-A of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2 and TEAD3 (By similarity). Interacts with TP73 (By similarity). Interacts with RUNX1 (By similarity). Interacts with TEAD4.

Function:

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction.

Subcellular Location:

Cytoplasm Nucleus Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.

Protein Attributes:

Sequence length:

488

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

488:

EGEELMPSLQ | EALSSEILDV | ESVLAATKLD | KESFLTWL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P46938

UniGene:

Mm.221992

Pfam:

PF00397

SMR:

P46938

KEGG:

mmu:22601

Uniprot:

P46938

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ELISA Kit for Mouse Yorkie homolog

Cat.:

E15210m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Yorkie homolog

Cat.:

E15210h

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Manual:

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96T

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ELISA Kit for Mouse Yorkie homolog

Cat.:

E15210r

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96T

ELISA Kit for Mouse Yorkie homolog

Cat.:

E15210c

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96T

CLIA Kit for Mouse Yorkie homolog

Cat.:

U15210r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Yorkie homolog

Cat.:

U15210m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Yorkie homolog

Cat.:

U15210h

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96T

CLIA Kit for Mouse Yorkie homolog

Cat.:

U15210c

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96T

Polyclonal Antibody for Mouse Yorkie homolog

Cat.:

P15210Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Yorkie homolog

Cat.:

P15210Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Yorkie homolog

Cat.:

P15210Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Yorkie homolog

Monoclonal Antibody for Mouse Yorkie homolog

Protein for Mouse Yorkie homolog

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain."
Sudol M. , Bork P. , Einbond A. , Kastury K. , Druck T. , Negrini M. , Huebner K. , Lehman D.
J. Biol. Chem.270:14733-14741(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: NIH Swiss.
tissue: Embryo.
2.

"WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus."
Komuro A. , Nagai M. , Navin N.E. , Sudol M.
J. Biol. Chem.278:33334-33341(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: 129.
strain: C57BL/6.
strain: FVB/N.
tissue: Brain.
tissue: Kidney.
tissue: Mammary gland.
5.

"The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules."
Chen H.I. , Sudol M.
Proc. Natl. Acad. Sci. U.S.A.92:7819-7823(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WBP1 AND WBP2
6.

"The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled."
Ermekova K.S. , Zambrano N. , Linn H. , Minopoli G. , Gertler F. , Russo T. , Sudol M.
J. Biol. Chem.272:32869-32877(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ENAH
7.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
8.

"Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."
Hoshino M. , Qi M.-L. , Yoshimura N. , Tagawa K. , Wada Y.-I. , Enokido Y. , Marubuchi S. , Harjes P. , Arai N. , Oyanagi K. , Blandino G. , Sudol M. , Rich T. , Kanazawa I. , Wanker E.E. , Saitoe M. , Okazawa H.
J. Cell Biol.172:589-604(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ISOFORMS LACKING THE TRANSCRIPTIONAL ACTIVATION DOMAIN;TISSUE SPECIFICITY
9.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
10.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
11.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
12.

"Structural basis of YAP recognition by TEAD4 in the hippo pathway."
Chen L. , Chan S.W. , Zhang X. , Walsh M. , Lim C.J. , Hong W. , Song H.
Genes Dev.24:290-300(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TEAD4;X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 47-85 IN COMPLEX WITH TEAD4
13.

"Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects."
UK10K Consortium , Williamson K.A. , Rainger J. , Floyd J.A. , Ansari M. , Meynert A. , Aldridge K.V. , Rainger J.K. , Anderson C.A. , Moore A.T. , Hurles M.E. , Clarke A. , van Heyningen V. , Verloes A. , Taylor M.S. , Wilkie A.O. , Fitzpatrick D.R. , Hurles M. , more...
Am. J. Hum. Genet.94:295-302(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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